Tmem189 Gene Summary [Mouse]
Enables plasmanylethanolamine desaturase activity. Involved in ether lipid biosynthetic process. Located in endoplasmic reticulum membrane. Orthologous to several human genes including PEDS1 (plasmanylethanolamine desaturase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem189 |
| Official Name | transmembrane protein 189 [Source:MGI Symbol;Acc:MGI:2142624] |
| Ensembl ID | ENSMUSG00000090213 |
| Bio databases IDs | |
| Aliases | transmembrane protein 189 |
| Synonyms | CarF, KUA, LOC686344, plasmanylethanolamine desaturase 1, TMEM189, Ubiquitin-conjugating enzyme e2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem189 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- Lipid desaturase domain
- plasmanylethanolamine desaturase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem189 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid metabolic process
- ether lipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- plasmanylethanolamine desaturase activity