Details
| Type | Immunoglobulin Constant Gene |
| Official Symbol | Igha |
| Official Name | immunoglobulin heavy constant alpha [Source:MGI Symbol;Acc:MGI:96444] |
| Ensembl ID | ENSMUSG00000095079 |
| Bio databases IDs | |
| Aliases | immunoglobulin heavy constant alpha |
| Species | Mouse, Mus musculus |
Pathways
Biological processes and signaling networks where the Igha gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- FcγRIIB Signaling in B Lymphocytes
- IL-15 Signaling
- IL-7 Signaling Pathway
- p70S6K Signaling
- Phagosome Formation
- PI3K Signaling in B Lymphocytes
- Role of NFAT in Regulation of the Immune Response
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
phenotypes
- abnormal T cell activation
- abnormal class switch recombination
- abnormal dendritic cell physiology
- abnormal immunoglobulin level
- abnormal memory T cell physiology
- decreased IgA level
- decreased IgE level
- decreased IgG3 level
- decreased T cell proliferation
- decreased interferon-gamma secretion
- increased B cell apoptosis
- increased B cell derived lymphoma incidence
- increased B cell proliferation
- increased IgG level
- increased IgG1 level
- increased IgG2a level
- increased IgG2b level
- increased IgM level
- increased interferon-gamma secretion
- increased interleukin-4 secretion
- increased plasma cell number
- increased susceptibility to Orthomyxoviridae infection
- increased susceptibility to parasitic infection