Trpc2 Gene Summary [Mouse]

Enables diacylglycerol binding activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Acts upstream of or within several processes, including female courtship behavior; inter-male aggressive behavior; and mating behavior, sex discrimination. Located in dendrite membrane and endomembrane system. Is expressed in brain; ganglia; genitourinary system; sensory organ; and skeletal muscle. Orthologous to human TRPC2 (transient receptor potential cation channel subfamily C member 2 (pseudogene)). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Trpc2
Official Name
transient receptor potential cation channel, subfamily C, member 2 [Source:MGI Symbol;Acc:MGI:109527]
Ensembl ID
ENSMUSG00000100254
Bio databases IDs NCBI: 22064 Ensembl: ENSMUSG00000100254
Aliases transient receptor potential cation channel, subfamily C, member 2
Synonyms 3010009O07RIK, AI115608, mTrp2, smTRPC2, transient receptor potential cation channel subfamily C member 2, transient receptor potential cation channel, subfamily C, member 2, trp2, TRPC2a, TRPC2b, Trrp2
Species
Mouse, Mus musculus
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trpc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • binding protein
  • Ion transport protein
  • diacylglycerol binding
  • Ankyrin repeats (3 copies)
  • Transient receptor ion channel II
  • transient-receptor-potential calcium channel protein
  • store-operated calcium channel
  • cytosolic tail domain
  • protein binding
  • ion channel
  • Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
  • Polycystin cation channel

Pathways

Biological processes and signaling networks where the Trpc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • cancer
  • melanoma cancer
regulated by
  • Gstp1 (includes others)
  • ASIP
  • Ca2+
  • phenylephrine
  • carbamylcholine
  • diacylglycerol
  • tetradecanoylphorbol acetate
  • thapsigargin
regulates
  • ERK1/2
  • cyclic AMP
  • Ca2+
  • TSHR
  • TG
role in cell
  • phosphorylation in
  • expression in
  • production in
  • function
  • abnormal morphology
  • elevation in
  • innervation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • endomembrane system
  • cellular membrane
  • microvilli
  • perikaryon
  • dendrites
  • dendritic knobs

Gene-Specific Assays for Results You Can Trust

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