Tg Gene Summary [Mouse]
Enables identical protein binding activity. Involved in thyroid hormone generation. Acts upstream of or within iodide transport; regulation of myelination; and thyroid hormone metabolic process. Located in extracellular space. Is expressed in thyroid gland; thyroid gland follicle; thyroid gland left lobe colloid-filled follicles; thyroid gland lobe; and thyroid gland right lobe colloid-filled follicles. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in autoimmune disease of endocrine system (multiple); goiter; liver disease (multiple); and thyroid dyshormonogenesis 3. Orthologous to human TG (thyroglobulin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tg |
| Official Name | thyroglobulin [Source:MGI Symbol;Acc:MGI:98733] |
| Ensembl ID | ENSMUSG00000053469 |
| Bio databases IDs | |
| Aliases | thyroglobulin |
| Synonyms | AITD3, cog, LOC102550922, T4, TGN, Thyroglobulin, THYROID HORMONE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Carboxylesterase family
- Tyrosine-protein kinase ephrin type A/B receptor-like
- alpha/beta hydrolases
- heparin binding domain
- protein binding
- receptor binding
- identical protein binding
- PDI binding domain
- thrombospondin type 3 repeat
- Thrombospondin type 2 repeat
- acetylcholinesterase homology domain
- binding protein
- TY
- chaperone binding
Pathways
Biological processes and signaling networks where the Tg gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- cold thyroid nodule
- susceptibility to autoimmune thyroid disease type 3
- hyperplasia
- Hashimoto thyroiditis
- thyroid dyshormonogenesis 3
- multinodular goiter
- adenomatous goiter
- pneumonia
- hypothyroidism
role in cell
- expression in
- migration
- proliferation
- quantity
- differentiation
- apoptosis
- swelling
- proton motive force
- hypertrophy
- frequency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- intracellular space
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- medial Golgi compartments
- membrane rafts
- plasma
- ER lumenal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- thyroid gland development
- signal transduction
- thyroid hormone generation
- regulation of myelination
- iodide transport
- hormone biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- hormone activity