Itprip Gene Summary [Mouse]
Enables protein kinase inhibitor activity. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors. Located in nuclear outer membrane. Orthologous to human ITPRIP (inositol 1,4,5-trisphosphate receptor interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itprip |
| Official Name | inositol 1,4,5-triphosphate receptor interacting protein [Source:MGI Symbol;Acc:MGI:3042776] |
| Ensembl ID | ENSMUSG00000117975 |
| Bio databases IDs | |
| Aliases | inositol 1,4,5-triphosphate receptor interacting protein |
| Synonyms | 4833424O12Rik, bA127L20, bA127L20.2, D1A, DANGER, inositol 1,4,5-triphosphate receptor interacting protein, inositol 1,4,5-trisphosphate receptor interacting protein, KIAA1754 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itprip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase inhibitor activity
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- outer nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itprip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- induction of apoptosis via death domain receptors
Cellular Component
Where in the cell the gene product is active
- membrane
- nuclear outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase inhibitor activity