Nrros Gene Summary [Mouse]
Enables receptor ligand inhibitor activity and transforming growth factor beta binding activity. Involved in several processes, including microglia development; sequestering of TGFbeta in extracellular matrix; and transforming growth factor beta receptor signaling pathway. Located in cell surface and endoplasmic reticulum. Is expressed in brain vascular element; embryo; and thymus primordium. Orthologous to human NRROS (negative regulator of reactive oxygen species). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrros |
| Official Name | negative regulator of reactive oxygen species [Source:MGI Symbol;Acc:MGI:2445095] |
| Ensembl ID | ENSMUSG00000052384 |
| Bio databases IDs | |
| Aliases | negative regulator of reactive oxygen species |
| Synonyms | E430025L02Rik, ELLP3030, GARPL1, Lrcc33, LRRC33, negative regulator of reactive oxygen species, RGD1310771, SENEBAC, UNQ3030 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrros often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- protein binding
- TGFbeta binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrros gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sequestering of TGFbeta in extracellular matrix
- inflammatory response
- immune response
- superoxide metabolic process
- innate immune response
- transforming growth factor beta receptor signaling pathway
- microglia development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- transforming growth factor beta binding