ITPRIP Gene Summary [Human]
This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | ITPRIP |
| Official Name | inositol 1,4,5-trisphosphate receptor interacting protein [Source:HGNC Symbol;Acc:HGNC:29370] |
| Ensembl ID | ENSG00000148841 |
| Bio databases IDs | |
| Aliases | inositol 1,4,5-trisphosphate receptor interacting protein |
| Synonyms | 4833424O12Rik, bA127L20, bA127L20.2, D1A, DANGER, inositol 1,4,5-triphosphate receptor interacting protein, inositol 1,4,5-trisphosphate receptor interacting protein, KIAA1754 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ITPRIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase inhibitor activity
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- outer nuclear membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ITPRIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- induction of apoptosis via death domain receptors
Cellular Component
Where in the cell the gene product is active
- membrane
- nuclear outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase inhibitor activity