Nuak2 Gene Summary [Rat]
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in cellular response to glucose starvation and protein phosphorylation. Predicted to be located in nuclear speck. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nuak2 |
| Official Name | NUAK family kinase 2 [Source:RGD Symbol;Acc:1359167] |
| Ensembl ID | ENSRNOG00000000034 |
| Bio databases IDs | |
| Aliases | NUAK family kinase 2 |
| Synonyms | 1200013B22Rik, ANPH2, mKIAA0537, NUAK family kinase 2, NUAK family, SNF1-like kinase, 2, Omphk2, SNARK, UV126 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nuak2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- Protein kinase domain
- magnesium ion binding
- Tyrosine kinase, catalytic domain
- phosphorylation site
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary central nervous system lymphoma
- primary cancer
- lymphomagenesis
- central nervous system cancer
- exencephaly
- weight gain
- anencephaly 2
- familial obesity
- adenoma formation
- gastrointestinal neoplasia
regulates
- CDK2
- D-glucose
- 2-deoxyglucose
- triacylglycerol
- fatty acid
role in cell
- expression in
- apoptosis
- motility
- response by
- organization
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nuak2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of hippo signaling cascade
- negative regulation of apoptotic process
- apoptotic process
- protein phosphorylation
- protein localization to nucleus
- actin cytoskeleton organization
- cellular response to glucose starvation
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- protein serine/threonine kinase activity