Slc26a1 Gene Summary [Rat]
Enables sulfate:bicarbonate antiporter activity. Involved in sulfate transmembrane transport. Located in basolateral plasma membrane. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human SLC26A1 (solute carrier family 26 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc26a1 |
| Official Name | solute carrier family 26 member 1 [Source:RGD Symbol;Acc:620136] |
| Ensembl ID | ENSRNOG00000000041 |
| Bio databases IDs | |
| Aliases | solute carrier family 26 member 1 |
| Synonyms | CAON, CAON1, EDM4, HYSULF, SAT-1, solute carrier family 26 member 1, solute carrier family 26 (sulfate transporter), member 1, solute carrier family 26 (sulphate transporter), member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc26a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfate:bicarbonate antiporter
- oxalate transporter
- Sulfate permease family
- PRK11660
- sulfate transporter
- high affinity sulphate transporter 1
- protein binding
- chloride transporter
- inorganic anion exchanger
- sulphate transporter and anti-sigma factor antagonist domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- kidney stones
- hyposulfatemia
- hypercalcemia
- mucopolysaccharidosis type I
- SLC26A1-related hypersulfaturia
- hypercalciuria
- hypersulfaturia
- polymyositis
- calcium oxalate nephrolithiasis type 1
regulates
- oxalic acid
- sulfate
- chloride
- GPT
- mineral
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc26a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sulfate transport
- oxalate transport
- chloride transport
- bicarbonate transport
Cellular Component
Where in the cell the gene product is active
- membrane
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sulfate:bicarbonate antiporter activity
- oxalate transmembrane transporter activity
- inorganic anion exchanger activity
- chloride transmembrane transporter activity
- bicarbonate transmembrane transporter activity
- sulfate transmembrane transporter activity