Klk6 Gene Summary [Rat]
Enables peptidase activity. Involved in regulation of neuron projection development. Predicted to be located in several cellular components, including extracellular region; intercellular bridge; and nucleus. Predicted to be active in cornified envelope; extracellular space; and secretory granule. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; demyelinating disease; and multiple system atrophy. Orthologous to human KLK6 (kallikrein related peptidase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klk6 |
| Official Name | kallikrein related-peptidase 6 [Source:RGD Symbol;Acc:3419] |
| Ensembl ID | ENSRNOG00000031927 |
| Bio databases IDs | |
| Aliases | kallikrein related-peptidase 6 |
| Synonyms | Bssp, hK6, KALLIKREIN 6, kallikrein related-peptidase 6, Klk7, Klni, Protease M, PRSS18, PRSS9, SP59 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klk6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- peptidase
- Domain of unknown function (DUF1986)
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Klk6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- atopic dermatitis
- colon cancer
- gastric cancer
- colorectal cancer
- pruritus
- uterine serous papillary cancer
- intestinal cancer
- serous ovarian adenocarcinoma
- serous ovarian cancer
role in cell
- expression in
- migration
- differentiation
- cell death
- survival
- cell-cell adhesion
- invasion
- development
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope
- Extracellular Space
- cytoplasmic bridges
- nucleoplasm
- nuclear envelope
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klk6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- regulation of cell differentiation
- response to wounding
- protein autoprocessing
- collagen catabolic process
- myelination
- amyloid precursor protein metabolic process
- regulation of neuron projection development
- tissue regeneration
- hormone metabolic process
- positive regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- extracellular space
- intercellular bridge
- nuclear membrane
- cytoplasm
- secretory granule
- mitochondrion
- endoplasmic reticulum
- nucleolus
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity