Apoa1 Gene Summary [Rat]
Enables amyloid-beta binding activity; cholesterol transfer activity; and lipase inhibitor activity. Involved in several processes, including negative regulation of lipase activity; peripheral nervous system axon regeneration; and response to estrogen. Located in cell surface and extracellular space. Part of discoidal high-density lipoprotein particle; intermediate-density lipoprotein particle; and low-density lipoprotein particle. Used to study arteriosclerosis and hyperthyroidism. Biomarker of several diseases, including artery disease (multiple); major depressive disorder; ocular hypertension; sciatic neuropathy; and steatotic liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; hypolipoproteinemia (multiple); metabolic dysfunction-associated steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apoa1 |
| Official Name | apolipoprotein A1 [Source:RGD Symbol;Acc:2130] |
| Ensembl ID | ENSRNOG00000045679 |
| Bio databases IDs | |
| Aliases | apolipoprotein A1 |
| Synonyms | Alp-1, AMYLD3, Apo1a, APO A, apo(a), APOA-I, APOLIPOPROTEIN A1, APOLIPOPROTEIN A-I, APOLIPOPROTEIN A-I G1, Brp-14, CSL112, HPALP2, LP(A-I), Ltw-1, Lvtw-1, Sep-1, Sep-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Apoa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- cholesterol binding
- lipid binding
- amphipathic helix
- chemorepellant
- heat shock protein binding
- enzyme inhibitor activity
- alpha helix
- high-density lipoprotein binding
- enzyme binding
- beta-amyloid binding
- protein binding
- receptor binding
- enzyme activator activity
- identical protein binding
- lipid transporter
- binding protein
- protein homodimerization
- receptor agonist activity
- Apolipoprotein A1/A4/E domain
- transporter
Pathways
Biological processes and signaling networks where the Apoa1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Atherosclerosis Signaling
- Clathrin-mediated Endocytosis Signaling
- FXR/RXR Activation
- IL-12 Signaling and Production in Macrophages
- LXR/RXR Activation
- Maturity Onset Diabetes of Young (MODY) Signaling
- PPARα/RXRα Activation
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pruritus
- cancer
- melanoma cancer
- atherosclerosis
- aortic valve calcification
- metabolic syndrome X
- familial amyloid polyneuropathy type III
- Apolipoprotein A-I deficiency
- epithelial cancer
role in cell
- differentiation
- apoptosis
- activation in
- degradation in
- phosphorylation in
- cell viability
- expression in
- cell death
- proliferation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- myelin enriched fraction
- nonraft domain
- secretory granule lumen
- Cytoplasm
- cell surface
- cell borders
- intracellular space
- organelle lumens
- membrane surface
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- trans Golgi network
- nuclear envelope
- early endosomes
- cytoplasmic vesicles
- endocytotic vesicle
- extracellular matrix
- membrane rafts
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Apoa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- negative regulation of response to cytokine stimulus
- negative chemotaxis
- negative regulation of interleukin-1 beta production
- transforming growth factor beta receptor signaling pathway
- acylglycerol homeostasis
- phospholipid homeostasis
- protein oxidation
- negative regulation of cytokine production involved in immune response
- triglyceride homeostasis
- cholesterol transport
- regulation of intestinal cholesterol absorption
- regulation of Cdc42 protein signal transduction
- negative regulation of cell adhesion molecule production
- high-density lipoprotein particle assembly
- G-protein coupled receptor signaling pathway
- negative regulation of inflammatory response
- high-density lipoprotein particle clearance
- cholesterol biosynthetic process
- positive regulation of substrate adhesion-dependent cell spreading
- vitamin transport
- phosphatidylcholine biosynthetic process
- positive regulation of stress fiber assembly
- negative regulation of very-low-density lipoprotein particle remodeling
- positive regulation of phagocytosis
- cholesterol import
- positive regulation of Rho protein signal transduction
- high-density lipoprotein particle remodeling
- cholesterol metabolic process
- lipoprotein biosynthetic process
- cholesterol homeostasis
- positive regulation of hydrolase activity
- integrin-mediated signaling pathway
- reverse cholesterol transport
- positive regulation of cholesterol efflux
- adrenal gland development
- positive regulation of cholesterol metabolic process
- glucocorticoid metabolic process
- blood vessel endothelial cell migration
- ERK1 and ERK2 cascade
- regulation of protein phosphorylation
- negative regulation of tumor necrosis factor-mediated signaling pathway
- endothelial cell proliferation
- negative regulation of heterotypic cell-cell adhesion
- cholesterol efflux
- protein stabilization
- phospholipid efflux
- peptidyl-methionine modification
Cellular Component
Where in the cell the gene product is active
- very-low-density lipoprotein particle
- chylomicron
- high-density lipoprotein particle
- low-density lipoprotein particle
- extracellular region
- plasma membrane
- endoplasmic reticulum lumen
- endocytic vesicle
- early endosome
- extracellular space
- extracellular vesicular exosome
- endocytic vesicle lumen
- blood microparticle
- cytosol
- cytoplasmic vesicle
- secretory granule lumen
- spherical high-density lipoprotein particle
Molecular Function
What the gene product does at the molecular level
- heat shock protein binding
- identical protein binding
- protein homodimerization activity
- cholesterol binding
- phosphatidylcholine-sterol O-acyltransferase activator activity
- high-density lipoprotein particle binding
- chemorepellent activity
- phospholipid binding
- receptor binding
- apolipoprotein A-I receptor binding
- beta-amyloid binding
- apolipoprotein receptor binding
- protein binding
- high-density lipoprotein particle receptor binding
- enzyme binding