Tst Gene Summary [Rat]
Predicted to enable 3-mercaptopyruvate sulfurtransferase activity; 5S rRNA binding activity; and thiosulfate-cyanide sulfurtransferase activity. Predicted to be involved in epithelial cell differentiation and rRNA import into mitochondrion. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human TST (thiosulfate sulfurtransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tst |
| Official Name | thiosulfate sulfurtransferase [Source:RGD Symbol;Acc:3913] |
| Ensembl ID | ENSRNOG00000000186 |
| Bio databases IDs | |
| Aliases | thiosulfate sulfurtransferase |
| Synonyms | RDS, RHODAN, Rhodanese, thiosulfate sulfurtransferase, thiosulfate sulfurtransferase, mitochondrial, thiosulfate sulphurtransferase, thiosulfate sulphurtransferase, mitochondrial |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tst often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfurtransferase
- 5S rRNA binding
- Rhodanese Homology Domain
- enzyme
- Rhodanese-like domain
- thiosulfate sulfurtransferase
- RHOD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- obesity
- non-small cell lung cancer
- Parkinson disease
- cervical cancer
- hepatitis B virus-related hepatocellular carcinoma
- hepatitis B surface antigen-negative hepatitis C virus negative hepatocellular carcinoma
regulates
- reactive oxygen species
- 5S
- cyanate
- sulfur amino acid
- sulfide
role in cell
- translation in
- differentiation
- perturbation
- disruption
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tst gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- sulfur amino acid catabolic process
- cyanate catabolic process
- rRNA import into mitochondrion
- rRNA transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- 5S rRNA binding
- thiosulfate sulfurtransferase activity
- 3-mercaptopyruvate sulfurtransferase activity