Ano10 Gene Summary [Rat]
Predicted to enable calcium-activated cation channel activity and intracellularly calcium-gated chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in cilium and intracellular membrane-bounded organelle. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 10. Orthologous to human ANO10 (anoctamin 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ano10 |
| Official Name | anoctamin 10 [Source:RGD Symbol;Acc:1308260] |
| Ensembl ID | ENSRNOG00000000219 |
| Bio databases IDs | |
| Aliases | anoctamin 10 |
| Synonyms | anoctamin 10, RGD1308260, SCAR10, TMEM16K |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ano10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium activated cation channel
- Calcium-activated chloride channel
- chloride channel
- intracellular calcium activated chloride channel
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- phosphatidylserine
- ion
- chloride
disease
- insomnia
- autosomal recessive spinocerebellar ataxia type 10
- major depression
- autosomal recessive cerebellar ataxia
- non-Hodgkin central nervous system lymphoma
- non-Hodgkin disease
- central nervous system cancer
- ichthyosis Chanarin Dorfman syndrome
- attention deficit hyperactivity disorder
- gastroesophageal reflux
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cilia
- intracellular space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ano10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium activated cation channel activity
- intracellular calcium activated chloride channel activity
- chloride channel activity