Bcap31 Gene Summary [Rat]
Predicted to enable MHC class I protein binding activity. Predicted to be involved in several processes, including positive regulation of proteolysis involved in protein catabolic process; positive regulation of retrograde protein transport, ER to cytosol; and protein localization to organelle. Predicted to act upstream of or within immune response. Located in Golgi cisterna membrane; clathrin-coated vesicle; and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in deafness, dystonia, and cerebral hypomyelination and sensorineural hearing loss. Orthologous to human BCAP31 (B cell receptor associated protein 31). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcap31 |
| Official Name | B-cell receptor-associated protein 31 [Source:RGD Symbol;Acc:1302944] |
| Ensembl ID | ENSRNOG00000055756 |
| Bio databases IDs | |
| Aliases | B-cell receptor-associated protein 31 |
| Synonyms | 6C6-AG, BAP31, B-cell receptor-associated protein 31, CDM, DDCH, DELXQ28, DXS1357E, MICRODELXq28, p28 Bap31 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Bcap31 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MHC class I protein binding
- binding protein
- cytoplasmic domain
- Bap31/Bap29 transmembrane region
- BAP31 intravesicular domain
- protein binding
- Bap31/Bap29 cytoplasmic coiled-coil domain
- transporter
Pathways
Biological processes and signaling networks where the Bcap31 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- severe motor and intellectual disabilities-sensorineural deafness-dystonia syndrome
- hereditary disorder
- obesity
- deafness, dystonia, and cerebral hypomyelination
- fibrosis
- impaired glucose tolerance
- impaired insulin tolerance
role in cell
- expression in
- phosphorylation in
- apoptosis
- production in
- proliferation
- growth
- formation in
- cell death
- transmembrane potential
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- secondary granule fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Plasma Membrane
- vesicles
- Endoplasmic Reticulum
- lipid droplets
- granules
- cytosol
- reticular perinuclear compartment
- endoplasmic reticulum membrane
- basolateral membrane
- Golgi membrane
- inner nuclear membrane
- nuclear envelope
- Golgi cisternae
- clathrin-coated vesicles
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Bcap31 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to mitochondrion
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- ER to Golgi vesicle-mediated transport
- spermatogenesis
- apoptotic process
- protein localization to endoplasmic reticulum exit site
- intracellular protein transport
- positive regulation of intrinsic apoptotic signaling pathway
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- ER-mitochondrion membrane contact site
- Golgi membrane
- endoplasmic reticulum
- plasma membrane
- endoplasmic reticulum membrane
- lipid particle
- perinuclear endoplasmic reticulum
- membrane
- cytosol
- clathrin-coated vesicle
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- MHC class I protein binding