ANO10 Gene Summary [Human]
The transmembrane protein encoded by this gene belongs to the anoctamin family of calcium-activated chloride channels, also known as the transmembrane 16 family. The encoded protein contains eight transmembrane domains with cytosolic N- and C-termini. Defects in this gene may cause autosomal recessive spinocerebellar ataxia-10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Details
| Type | Processed Transcript |
| Official Symbol | ANO10 |
| Official Name | anoctamin 10 [Source:HGNC Symbol;Acc:HGNC:25519] |
| Ensembl ID | ENSG00000160746 |
| Bio databases IDs | |
| Aliases | anoctamin 10 |
| Synonyms | anoctamin 10, RGD1308260, SCAR10, TMEM16K |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANO10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium activated cation channel
- Calcium-activated chloride channel
- chloride channel
- intracellular calcium activated chloride channel
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- autosomal recessive spinocerebellar ataxia type 10
- major depression
- autosomal recessive cerebellar ataxia
- non-Hodgkin central nervous system lymphoma
- non-Hodgkin disease
- central nervous system cancer
- ichthyosis Chanarin Dorfman syndrome
- attention deficit hyperactivity disorder
- gastroesophageal reflux
regulates
- phosphatidylserine
- ion
- chloride
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cilia
- intracellular space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANO10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium activated cation channel activity
- intracellular calcium activated chloride channel activity
- chloride channel activity