Nfkbil1 Gene Summary [Rat]
Predicted to enable transcription regulator inhibitor activity. Predicted to be involved in cellular response to lipopolysaccharide; negative regulation of signal transduction; and regulation of gene expression. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human NFKBIL1 (NFKB inhibitor like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nfkbil1 |
| Official Name | NFKB inhibitor like 1 [Source:RGD Symbol;Acc:1303310] |
| Ensembl ID | ENSRNOG00000000839 |
| Bio databases IDs | |
| Aliases | NFKB inhibitor like 1 |
| Synonyms | Def-7, IkappaBL, IKBL, NFKBIL, NFKB inhibitor like 1, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1, nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor like 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nfkbil1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- insulin-dependent diabetes mellitus
- disorder of pregnancy
- susceptibility to rheumatoid arthritis
- allergic asthma
- COVID-19
- multiple sclerosis
- organismal death
- nephrosis
- late-onset myasthenia gravis
regulates
- TNF
- NFkB (complex)
role in cell
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nfkbil1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- negative regulation of toll-like receptor signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of tumor necrosis factor production
- negative regulation of lipopolysaccharide-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding