NFKBIL1 Gene Summary [Human]
This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Details
| Type | Protein Coding |
| Official Symbol | NFKBIL1 |
| Official Name | NFKB inhibitor like 1 [Source:HGNC Symbol;Acc:HGNC:7800] |
| Ensembl ID | ENSG00000204498 |
| Bio databases IDs | |
| Aliases | NFKB inhibitor like 1, NF-kappa-B inhibitor-like protein 1 |
| Synonyms | Def-7, IkappaBL, IKBL, NFKBIL, NFKB inhibitor like 1, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1, nuclear factor of κ light polypeptide gene enhancer in B cells inhibitor like 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFKBIL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- insulin-dependent diabetes mellitus
- disorder of pregnancy
- susceptibility to rheumatoid arthritis
- allergic asthma
- COVID-19
- multiple sclerosis
- organismal death
- nephrosis
- late-onset myasthenia gravis
regulates
- TNF
- NFkB (complex)
role in cell
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFKBIL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- negative regulation of toll-like receptor signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of tumor necrosis factor production
- negative regulation of lipopolysaccharide-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding