Ddah2 Gene Summary [Rat]
Predicted to be located in mitochondrion. Orthologous to human DDAH2 (DDAH family member 2, ADMA-independent). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ddah2 |
| Official Name | dimethylarginine dimethylaminohydrolase 2 [Source:RGD Symbol;Acc:1302955] |
| Ensembl ID | ENSRNOG00000000842 |
| Bio databases IDs | |
| Aliases | dimethylarginine dimethylaminohydrolase 2 |
| Synonyms | 1110003M04Rik, AU019324, DDAH, DDAH family member 2, ADMA-independent, DDAHII, G6a, HEL-S-277, NG30 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ddah2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- dimethylargininase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- early missed abortion
regulates
- VEGF
- SCGN
- nitric oxide
- insulin
- proinsulin
- D-glucose
- N,N-dimethylarginine
role in cell
- expression in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ddah2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of nitric oxide biosynthetic process
- citrulline metabolic process
- negative regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- dimethylargininase activity
- protein binding