Atp1b1 Gene Summary [Rat]
Enables P-type sodium:potassium-exchanging transporter activity and protein heterodimerization activity. Involved in potassium ion transport; response to hypoxia; and sodium ion transport. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of sodium:potassium-exchanging ATPase complex. Biomarker of sensorineural hearing loss. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human ATP1B1 (ATPase Na+/K+ transporting subunit beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp1b1 |
| Official Name | ATPase Na+/K+ transporting subunit beta 1 [Source:RGD Symbol;Acc:2170] |
| Ensembl ID | ENSRNOG00000002934 |
| Bio databases IDs | |
| Aliases | ATPase Na+/K+ transporting subunit beta 1 |
| Synonyms | ATP1B, Atp4b, ATPase, Na+/K+ transporting, beta 1 polypeptide, ATPase Na+/K+ transporting subunit beta 1, ATPase Na+/K+ transporting subunit β 1, ATPase, Na+/K+ transporting, β 1 polypeptide, Atpb, Atpb-1, ATPBS, Na K atpase β-1, Na,K-ATPase β subunit 1, NKbeta1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp1b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase stimulator
- ATPase binding
- protein kinase binding
- protein binding activity, bridging
- Na+/K+-exchanging ATPase
- protein binding
- cytosolic tail domain
- ATPase
- Sodium / potassium ATPase beta chain
- protein heterodimerization
- transporter
Pathways
Biological processes and signaling networks where the Atp1b1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- hypertension
- psoriasis
- squamous-cell carcinoma
- liver cancer
- epithelial cancer
- neurodegeneration
- venous thromboembolism
- coronary artery disease
- juvenile rheumatoid arthritis
role in cell
- expression in
- activation in
- phosphorylation in
- development
- replication in
- K63 polyubiquitination in
- repolarization
- induction in
- homeostasis in
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- myelin enriched fraction
- pH resistant lipid raft fraction
- cell surface
- apical compartment
- perinuclear region
- intracellular membranes
- cellular membrane
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- intercellular junctions
- cell-cell contacts
- basolateral cell surfaces
- microsome
- apical membrane
- caveolae
- basolateral membrane
- lateral plasma membrane
- sperm tail
- sarcolemma
- endolysosomes
- transverse tubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp1b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane repolarization involved in regulation of cardiac muscle cell action potential
- positive regulation of ATPase activity
- cellular sodium ion homeostasis
- cell adhesion
- membrane repolarization
- cardiac muscle contraction
- cellular calcium ion homeostasis
- cellular potassium ion homeostasis
- innate immune response
- ATP metabolic process
- establishment or maintenance of transmembrane electrochemical gradient
- regulation of gene expression
- sodium ion transmembrane transport
- cell communication by electrical coupling involved in cardiac conduction
- protein stabilization
- regulation of cardiac muscle contraction by calcium ion signaling
- protein localization in plasma membrane
- relaxation of cardiac muscle
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- sodium:potassium-exchanging ATPase complex
- organelle membrane
- plasma membrane
- T-tubule
- extracellular vesicular exosome
- sarcolemma
- membrane
- intercalated disc
- sperm flagellum
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- sodium:potassium-exchanging ATPase activity
- protein heterodimerization activity
- MHC class II protein complex binding
- protein binding, bridging
- ATPase activator activity
- ATPase binding