Rbmx Gene Summary [Rat]
Enables single-stranded RNA binding activity. Involved in mRNA splice site recognition; positive regulation of DNA-templated transcription; and regulation of postsynapse organization. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in X-linked mental retardation Gustavson type and syndromic X-linked intellectual disability Shashi type. Orthologous to several human genes including RBMX (RNA binding motif protein X-linked). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbmx |
| Official Name | RNA binding motif protein, X-linked [Source:RGD Symbol;Acc:1565256] |
| Ensembl ID | ENSRNOG00000000866 |
| Bio databases IDs | |
| Aliases | RNA binding motif protein, X-linked |
| Synonyms | GUST, HNRNPG, HNRPG, MENTAL RETARDATION WITH OPTIC ATROPHY, DEAFNESS, AND SEIZURES, MRXS11, MRXSG, MRXSH, RBMXP1, RBMXRT, RNA binding motif protein, X chromosome, RNA binding motif protein X-linked, RNA binding motif protein, X-linked, RNMX |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rbmx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RGG domain
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- nucleic acid binding
- mRNA binding
- chromatin binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- single-stranded RNA binding
- RNA binding
- double-stranded DNA binding
- RBM1CTR (NUC064) family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- androgenic alopecia
- colon epithelial cancer
- renal clear cell adenocarcinoma
- acute myeloid leukemia
- hepatocellular carcinoma
role in cell
- proliferation
- expression in
- growth
- cisplatin resistance
- migration
- alternative splicing by
- invasion by
- colony formation by
- production in
- migratory capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- catalytic step 2 spliceosome
- Mitochondria
- spliceosomes
- nucleoplasm
- nucleoli
- chromatin
- postsynaptic density
- exosomes
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rbmx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane protein ectodomain proteolysis
- positive regulation of nuclear mRNA splicing, via spliceosome
- regulation of alternative nuclear mRNA splicing, via spliceosome
- negative regulation of nuclear mRNA splicing, via spliceosome
- cellular response to interleukin-1
- osteoblast differentiation
- protein homooligomerization
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- euchromatin
- extracellular space
- extracellular vesicular exosome
- catalytic step 2 spliceosome
- membrane
- spliceosomal complex
- supraspliceosomal complex
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- identical protein binding
- RNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- mRNA binding
- chromatin binding