Tet2 Gene Summary [Rat]
Predicted to enable DNA 5-methylcytosine dioxygenase activity; ferrous iron binding activity; and zinc ion binding activity. Predicted to be involved in hemopoiesis; positive regulation of transcription by RNA polymerase II; and protein O-linked glycosylation. Predicted to act upstream of or within several processes, including hematopoietic stem cell homeostasis; myeloid progenitor cell differentiation; and positive regulation of gene expression, epigenetic. Predicted to be located in chromosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tet2 |
| Official Name | tet methylcytosine dioxygenase 2 [Source:RGD Symbol;Acc:1311625] |
| Ensembl ID | ENSRNOG00000023579 |
| Bio databases IDs | |
| Aliases | tet methylcytosine dioxygenase 2 |
| Synonyms | Ayu17-449, E130014J05Rik, FLJ20032, IMD75, KIAA1546, MDS, mKIAA1546, RGD1311625, tet methylcytosine dioxygenase 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tet2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ferrous iron binding
- Oxygenase domain of the 2OGFeDO superfamily
- zinc ion binding
- catalytic domain
- 2-oxoglutarate:oxygen oxidoreductase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Tet2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- prostate cancer
- chronic obstructive pulmonary disease
- thrombosis
- liver cancer
- liver neoplasia
- digestive system cancer
role in cell
- quantity
- proliferation
- differentiation
- growth
- expression in
- migration
- apoptosis
- survival
- production in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tet2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukocyte differentiation
- protein O-linked glycosylation
- 5-methylcytosine catabolic process
- myeloid cell differentiation
- response to organic cyclic compound
- positive regulation of transcription from RNA polymerase II promoter
- hypomethylation of CpG island
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- ferrous iron binding
- methylcytosine dioxygenase activity