Kmt5a Gene Summary [Rat]
The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation. [provided by RefSeq, May 2016]
Details
| Type | Protein Coding |
| Official Symbol | Kmt5a |
| Official Name | lysine methyltransferase 5A [Source:RGD Symbol;Acc:1587560] |
| Ensembl ID | ENSRNOG00000001062 |
| Bio databases IDs | |
| Aliases | lysine methyltransferase 5A |
| Synonyms | 2410195B05Rik, LOC687538, lysine methyltransferase 5A, PR/SET07, PR-SET7, PR-Set7 H4-K20, RGD1305893, SET07, SET8, SETD8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kmt5a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lysine N-methyltransferase
- protein-lysine N-methyltransferase
- histone lysine N-methyltransferase activity (H4-K20 specific)
- histone methyltransferase
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- catalytic domain
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- transcription co-repressor
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- Alzheimer disease
- osteoarthritis
- insomnia
- uterine leiomyoma
- leiomyomatosis
role in cell
- expression in
- phosphorylation in
- apoptosis
- migration
- invasion by
- proliferation
- cell cycle progression
- differentiation
- transcription in
- condensation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kmt5a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of DNA damage response, signal transduction by p53 class mediator
- cell division
- chromatin remodeling
- mitotic chromosome condensation
- negative regulation of transcription, DNA-dependent
- negative regulation of double-strand break repair via homologous recombination
- peptidyl-lysine monomethylation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- polytene chromosome
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity
- histone methyltransferase activity
- lysine N-methyltransferase activity
- protein-lysine N-methyltransferase activity
- histone methyltransferase activity (H4-K20 specific)