Hcfc1 Gene Summary [Rat]
Predicted to enable several functions, including DNA binding activity; identical protein binding activity; and transcription coactivator activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of transcription by RNA polymerase II. Located in axon; dendrite; and nuclear chromosome. Human ortholog(s) of this gene implicated in methylmalonic acidemia and homocysteinemia cblX type. Orthologous to human HCFC1 (host cell factor C1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hcfc1 |
| Official Name | host cell factor C1 [Source:RGD Symbol;Acc:1563804] |
| Ensembl ID | ENSRNOG00000051948 |
| Bio databases IDs | |
| Aliases | host cell factor C1 |
| Synonyms | CFF, HCF, HCF-1, HFC1, host cell factor C1, LOC100911260, MAHCX, MRX3, PPP1R89, RGD1563804, VCAF, XLID3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hcfc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HCF-1 proteolytic repeat
- Kelch motif
- activation domain
- transcription regulator
- beta propeller
- transcription co-activator
- nucleic acid binding
- protein binding activity, bridging
- nuclear localization sequence
- transcription activation domain
- transcription factor binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- zDHHC ankyrin repeat binding domain
- acidic domain
- DNA binding
- Galactose oxidase, central domain
- FN3
- double-stranded DNA binding
- chromatin binding domain
- basic domain
- WYF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- methylmalonic acidemia with homocystinuria
- hereditary disorder
- methylmalonic acidemia with homocysteinemia cblX type
- mental retardation
- methylmalonic aciduria with homocystinuria cblC type
- chronic periodontal disease
- X-linked mental retardation
- Turner syndrome
role in cell
- binding in
- expression in
- quantity
- apoptosis
- transactivation in
- multinucleation
- alignment
- secretion in
- segregation
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- Cytoplasm
- gems
- chromosome
- nucleoplasm
- nuclear bodies
- nuclear speckles
- Cajal bodies
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hcfc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- regulation of protein complex assembly
- reactivation of latent virus
- positive regulation of cell cycle
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- Set1C/COMPASS complex
- nucleus
- cytoplasm
- histone methyltransferase complex
- membrane
- macromolecular complex
- neuronal cell body
- NSL complex
- histone acetyltransferase complex
- MLL1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transcription coactivator activity
- cadherin binding
- chromatin binding
- protein binding, bridging