L3mbtl2 Gene Summary [Rat]
Predicted to enable methylated histone binding activity and promoter-specific chromatin binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including ectoderm development; stem cell differentiation; and stem cell proliferation. Predicted to be active in nucleus. Orthologous to human L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | L3mbtl2 |
| Official Name | L3MBTL histone methyl-lysine binding protein 2 [Source:RGD Symbol;Acc:1308569] |
| Ensembl ID | ENSRNOG00000024743 |
| Bio databases IDs | |
| Aliases | L3MBTL histone methyl-lysine binding protein 2 |
| Synonyms | 4732493N06Rik, dJ756G23.3, H-l(3)mbt-l, L3MBT, L3MBTL2 polycomb repressive complex 1 subunit, L3MBTL histone methyl-lysine binding protein 2, M4mbt |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat L3mbtl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
- mbt repeat
- protein binding activity, bridging
- chromatin binding
- protein binding
- malignant brain tumor (MBT) repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- neuroticism
- major depression
role in cell
- apoptosis
- expression in
- proliferation
- differentiation
- organization
- mono-ubiquitination in
- repression in
- compaction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat L3mbtl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- histone binding
- methylated histone residue binding
- chromatin binding