Mphosph9 Gene Summary [Rat]
Predicted to be involved in negative regulation of cilium assembly. Predicted to be located in Golgi apparatus and centrosome. Predicted to be active in centriole. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human MPHOSPH9 (M-phase phosphoprotein 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mphosph9 |
| Official Name | M-phase phosphoprotein 9 [Source:RGD Symbol;Acc:1598368] |
| Ensembl ID | ENSRNOG00000001074 |
| Bio databases IDs | |
| Aliases | M-phase phosphoprotein 9 |
| Synonyms | 4930548D04Rik, 9630025B04RIK, B930097C17RIK, M-phase phosphoprotein 9, MPP-9 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mphosph9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Ciliary protein causing Leber congenital amaurosis disease
- protein binding
- Domain of unknown function (DUF4472)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- non-insulin-dependent diabetes mellitus
- venous thromboembolism
- chronic obstructive pulmonary disease
- multiple sclerosis
- major depression
- insomnia
- small cell lung cancer
- irritable bowel syndrome
- osteoarthritis
regulates
role in cell
- cell death
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- Golgi Apparatus
- centriole
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mphosph9 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- centrosome
- centriole
- membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding