Ube2d1 Gene Summary [Rat]
Enables ubiquitin-protein transferase activity. Predicted to be involved in several processes, including negative regulation of TORC1 signaling; positive regulation of protein ubiquitination; and protein K48-linked ubiquitination. Predicted to act upstream of or within positive regulation of protein polyubiquitination and protein polyubiquitination. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human UBE2D1 (ubiquitin conjugating enzyme E2 D1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2d1 |
| Official Name | ubiquitin-conjugating enzyme E2D 1 [Source:RGD Symbol;Acc:1307886] |
| Ensembl ID | ENSRNOG00000000611 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2D 1 |
| Synonyms | E2(17)KB1, E2 H5A, LOC105378315, SFT, UBC4/5, UBC5, UBC5A, UBCH5, UBCH5A, ubiquitin-conjugating enzyme E2D 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ube2d1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2d1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- androgenic alopecia
- alcoholic liver disease
- organismal death
- lung adenocarcinoma formation
- neonatal late-onset sepsis
- lung adenocarcinoma
- chronic lymphocytic leukemia
- overall survival
- gastrointestinal disturbance
role in cell
- expression in
- proliferation
- migration
- downregulation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ube2d1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- protein polyubiquitination
- positive regulation of protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ATP binding
- protein binding
- ubiquitin protein ligase binding