Ube2d3 Gene Summary [Rat]
Enables ubiquitin-protein transferase activity. Involved in cellular response to cadmium ion; cellular response to mercury ion; and ubiquitin-dependent protein catabolic process. Predicted to be located in endosome membrane and plasma membrane. Predicted to be active in nucleus. Orthologous to human UBE2D3 (ubiquitin conjugating enzyme E2 D3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2d3 |
| Official Name | ubiquitin-conjugating enzyme E2D 3 [Source:RGD Symbol;Acc:619912] |
| Ensembl ID | ENSRNOG00000013741 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2D 3 |
| Synonyms | 1100001F19RIK, 9430029A22Rik, E2(17)KB3, LOC100128180, UBC4/5, UBCH5C, UBIQUITIN CONJUGATING ENZYME E2D3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ube2d3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2d3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- non-insulin-dependent diabetes mellitus
- lung adenocarcinoma
- lung adenocarcinoma formation
- overall survival
role in cell
- degradation in
- growth
- differentiation
- proliferation
- formation
- cell cycle progression
- invasiveness
- phagocytosis
- phagocytosis by
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ube2d3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- protein modification process
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- protein polyubiquitination
- protein monoubiquitination
- ubiquitin-dependent protein catabolic process
- negative regulation of BMP signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- proteasomal ubiquitin-dependent protein catabolic process
- apoptotic process
- protein K6-linked ubiquitination
- protein autoubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- ubiquitin ligase complex
- cytosol
- endosome membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ubiquitin-protein ligase activity
- protein binding
- ubiquitin protein ligase binding