Tlr3 Gene Summary [Rat]
Enables double-stranded RNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to exogenous dsRNA; and microglial cell activation. Located in cell surface. Used to study asthma. Biomarker of colitis; pancreatitis; perinatal necrotizing enterocolitis; peripheral nervous system disease; and pre-eclampsia. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tlr3 |
| Official Name | toll-like receptor 3 [Source:RGD Symbol;Acc:735171] |
| Ensembl ID | ENSRNOG00000021726 |
| Bio databases IDs | |
| Aliases | toll-like receptor 3 |
| Synonyms | CD283, IIAE2, IMD83, toll-like receptor 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tlr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein phosphatase 1 regulatory subunit 42
- signaling receptor activity
- cytoplasmic linker
- ectodomain
- SEFIR domain
- Leucine rich repeat
- enzyme binding
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- identical protein binding
- phosphorylation site
- leucine-rich repeat
- cytoplasmic domain
- Toll-like receptor 3 trans-membrane domain
- double-stranded RNA binding
- transmembrane domain
- intracellular domain
- Leucine rich repeat N-terminal domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Tlr3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Colorectal Cancer Metastasis Signaling
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Dendritic Cell Maturation
- IL-12 Signaling and Production in Macrophages
- LXR/RXR Activation
- Neuroinflammation Signaling Pathway
- NF-κB Signaling
- Phagosome Formation
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PKR in Interferon Induction and Antiviral Response
- Toll-like Receptor Signaling
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- neoplasia
- X-linked agammaglobulinemia
- pneumonitis
- Immunodeficiency-83
- experimental hepatitis
- rheumatoid arthritis
- Graves disease
- acinar to ductal metaplasia
- psoriasis
role in cell
- expression in
- proliferation
- migration
- accumulation in
- invasion by
- signaling in
- phosphorylation in
- activation
- differentiation
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular compartment
- Cytoplasm
- cell surface
- intracellular space
- membrane surface
- cellular membrane
- endosomes
- vesicles
- lysosome
- Endoplasmic Reticulum
- granules
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- lysosome membrane
- endosomal compartment
- endosomal membrane
- perinuclear space
- early endosomes
- late endosomes
- cytoplasmic vesicles
- endocytotic vesicle
- multivesicular bodies
- endolysosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tlr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- I-kappaB phosphorylation
- male gonad development
- activation of NF-kappaB-inducing kinase activity
- extrinsic apoptotic signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- JNK cascade
- detection of virus
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of angiogenesis
- positive regulation of macrophage cytokine production
- regulation of dendritic cell cytokine production
- positive regulation of interferon-alpha production
- response to exogenous dsRNA
- positive regulation of interferon-beta production
- negative regulation of osteoclast differentiation
- positive regulation of interferon-gamma production
- positive regulation of type III interferon production
- defense response to virus
- positive regulation of tumor necrosis factor production
- positive regulation of chemokine production
- cellular response to interferon-beta
- type III interferon production
- signal transduction
- positive regulation of inflammatory response
- response to dsRNA
- defense response to bacterium
- hyperosmotic response
- toll-like receptor signaling pathway
- microglial cell activation
- cellular response to mechanical stimulus
- positive regulation of interleukin-12 production
- positive regulation of interleukin-8 production
- cellular response to exogenous dsRNA
- positive regulation of JNK cascade
- positive regulation of gene expression
- innate immune response
- positive regulation of apoptotic process
- toll-like receptor 3 signaling pathway
- cellular response to xenobiotic stimulus
- cellular response to interferon-gamma
- positive regulation of interleukin-6 production
Cellular Component
Where in the cell the gene product is active
- endolysosome membrane
- Golgi membrane
- plasma membrane
- lysosomal membrane
- cell surface
- endoplasmic reticulum membrane
- extracellular space
- early endosome
- cytoplasm
- membrane
- endosome membrane
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- transmembrane signaling receptor activity
- protein binding
- double-stranded RNA binding
- signaling receptor activity