Wipi2 Gene Summary [Rat]
Predicted to enable phosphatidylinositol phosphate binding activity and protein-macromolecule adaptor activity. Predicted to be involved in autophagy of mitochondrion; cellular response to starvation; and macroautophagy. Predicted to act upstream of or within protein lipidation involved in autophagosome assembly and xenophagy. Predicted to be located in several cellular components, including autophagosome; nucleoplasm; and phagophore assembly site. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and phagophore assembly site membrane. Orthologous to human WIPI2 (WD repeat domain, phosphoinositide interacting 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wipi2 |
| Official Name | WD repeat domain, phosphoinositide interacting 2 [Source:RGD Symbol;Acc:1359154] |
| Ensembl ID | ENSRNOG00000001114 |
| Bio databases IDs | |
| Aliases | WD repeat domain, phosphoinositide interacting 2 |
| Synonyms | 1110018O08Rik, 2510001I10Rik, ATG18B, Atg21, CGI-50, IDDSSA, WD repeat domain, phosphoinositide interacting 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wipi2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- WD40
- protein binding
- phosphatidylinositol binding
Pathways
Biological processes and signaling networks where the Wipi2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- non-insulin-dependent diabetes mellitus
- major depression
- Alzheimer disease
- colorectal cancer
- intellectual developmental disorder with short stature and variable skeletal anomalies
- multiple sclerosis
role in cell
- expression in
- response
- cell death
- proliferation
- degradation in
- growth
- cell viability
- assembly
- mitophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- nucleoplasm
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wipi2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- protein localization to pre-autophagosomal structure
- protein lipidation
- peroxisome degradation
- cellular response to starvation
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- pre-autophagosomal structure membrane
- pre-autophagosomal structure
- membrane
- cytosol
- macromolecular complex
- extrinsic to membrane
- autophagic vacuole
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding