Wipi2 Gene Summary [Mouse]
Enables phosphatidylinositol-3-phosphate binding activity. Acts upstream of or within protein lipidation involved in autophagosome assembly; protein localization to phagophore assembly site; and xenophagy. Located in autophagosome and phagophore assembly site. Is expressed in several structures, including cranial ganglion; dorsal root ganglion; submandibular gland primordium; telencephalon; and vibrissa epidermal component. Orthologous to human WIPI2 (WD repeat domain, phosphoinositide interacting 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Wipi2 |
| Official Name | WD repeat domain, phosphoinositide interacting 2 [Source:MGI Symbol;Acc:MGI:1923831] |
| Ensembl ID | ENSMUSG00000029578 |
| Bio databases IDs | |
| Aliases | WD repeat domain, phosphoinositide interacting 2 |
| Synonyms | 1110018O08Rik, 2510001I10Rik, ATG18B, Atg21, CGI-50, IDDSSA, WD repeat domain, phosphoinositide interacting 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wipi2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- WD40
- protein binding
- phosphatidylinositol binding
Pathways
Biological processes and signaling networks where the Wipi2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- non-insulin-dependent diabetes mellitus
- major depression
- Alzheimer disease
- colorectal cancer
- intellectual developmental disorder with short stature and variable skeletal anomalies
- multiple sclerosis
role in cell
- expression in
- response
- cell death
- proliferation
- degradation in
- growth
- cell viability
- assembly
- mitophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- nucleoplasm
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wipi2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- protein localization to pre-autophagosomal structure
- protein lipidation
- peroxisome degradation
- cellular response to starvation
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- pre-autophagosomal structure membrane
- pre-autophagosomal structure
- membrane
- cytosol
- macromolecular complex
- extrinsic to membrane
- autophagic vacuole
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding