WIPI2 Gene Summary [Human]
WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | WIPI2 |
| Official Name | WD repeat domain, phosphoinositide interacting 2 [Source:HGNC Symbol;Acc:HGNC:32225] |
| Ensembl ID | ENSG00000157954 |
| Bio databases IDs | |
| Aliases | WD repeat domain, phosphoinositide interacting 2 |
| Synonyms | 1110018O08Rik, 2510001I10Rik, ATG18B, Atg21, CGI-50, IDDSSA, WD repeat domain, phosphoinositide interacting 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WIPI2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- WD40
- protein binding
- phosphatidylinositol binding
Pathways
Biological processes and signaling networks where the WIPI2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- non-insulin-dependent diabetes mellitus
- major depression
- Alzheimer disease
- colorectal cancer
- intellectual developmental disorder with short stature and variable skeletal anomalies
- multiple sclerosis
role in cell
- expression in
- response
- cell death
- proliferation
- degradation in
- growth
- cell viability
- assembly
- mitophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- nucleoplasm
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WIPI2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- protein localization to pre-autophagosomal structure
- protein lipidation
- peroxisome degradation
- cellular response to starvation
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- pre-autophagosomal structure membrane
- pre-autophagosomal structure
- membrane
- cytosol
- macromolecular complex
- extrinsic to membrane
- autophagic vacuole
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding