Sirt4 Gene Summary [Rat]
Predicted to enable several functions, including NAD+ binding activity; NAD+ poly-ADP-ribosyltransferase activity; and acyltransferase activity, transferring groups other than amino-acyl groups. Involved in cellular response to hypoxia; negative regulation of cardiac muscle cell apoptotic process; and negative regulation of protein processing involved in protein targeting to mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial matrix. Biomarker of metabolic dysfunction-associated steatotic liver disease. Orthologous to human SIRT4 (sirtuin 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sirt4 |
| Official Name | sirtuin 4 [Source:RGD Symbol;Acc:1310413] |
| Ensembl ID | ENSRNOG00000001151 |
| Bio databases IDs | |
| Aliases | sirtuin 4 |
| Synonyms | 4930596O17RIK, SIR2L4, sirtuin 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sirt4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pentosyltransferase
- NAD ADP-ribosyltransferase
- linear amide carbon-nitrogen bond hydrolase
- enzyme
- protein binding
- SIR2
- Non-amino-acyl group acyltransferase
Pathways
Biological processes and signaling networks where the Sirt4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- gastric cancer
- obesity
- thyroid cancer
- colon cancer
- bladder cancer
- ovarian cancer
- nonalcoholic fatty liver disease
regulated by
- APP
- valproic acid
- NAD+
- camptothecin
- D-glucose
- resveratrol
- MTORC1
- cigarette smoke
- niacinamide
- cycloheximide
role in cell
- expression in
- ferroptosis
- phosphorylation in
- proliferation
- apoptosis
- activation in
- cell death
- organization
- transmembrane potential
- deacetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sirt4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamine metabolic process
- regulation of glutamine family amino acid metabolic process
- negative regulation of insulin secretion
- response to DNA damage stimulus
- mitochondrion organization
- regulation of gene expression, epigenetic
- positive regulation of lipid biosynthetic process
- tricarboxylic acid metabolic process
- negative regulation of fatty acid oxidation
- peptidyl-lysine deacetylation
- negative regulation of cardiac muscle cell apoptotic process
- cellular response to hypoxia
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- nucleotidyltransferase activity
- zinc ion binding
- NAD-dependent protein deacetylase activity
- protein binding
- histone deacetylase activity
- NAD+ binding
- NAD+ ADP-ribosyltransferase activity