Mlycd Gene Summary [Rat]
Enables malonyl-CoA decarboxylase activity. Involved in several processes, including fatty acid metabolic process; regulation of small molecule metabolic process; and response to ischemia. Located in mitochondrial matrix and peroxisomal matrix. Biomarker of metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in cardiomyopathy. Orthologous to human MLYCD (malonyl-CoA decarboxylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mlycd |
| Official Name | malonyl-CoA decarboxylase [Source:RGD Symbol;Acc:620234] |
| Ensembl ID | ENSRNOG00000014522 |
| Bio databases IDs | |
| Aliases | malonyl-CoA decarboxylase |
| Synonyms | MALONYL COA DECARBOXYLASE, MCD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mlycd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Malonyl-CoA decarboxylase N-terminal domain
- mitochondrial presequence
- Malonyl-CoA decarboxylase C-terminal domain
- enzyme
- protein binding
- peroxisome targeting signal
- identical protein binding
- malonyl-CoA decarboxylase
Pathways
Biological processes and signaling networks where the Mlycd gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- malonic aciduria
- hypotonia
- liver disease
- organismal death
- mental retardation
- renal clear cell adenocarcinoma
- renal clear cell cancer
- insulin resistance
role in cell
- accumulation in
- expression in
- proliferation
- phosphorylation in
- production in
- fragmentation
- expansion
- ferroptosis
- fragmentation in
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- Mitochondria
- cytosol
- mitochondrial matrix
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mlycd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- malonyl-CoA catabolic process
- regulation of fatty acid beta-oxidation
- response to ischemia
- regulation of glucose metabolic process
- positive regulation of fatty acid oxidation
- fatty acid oxidation
- acetyl-CoA biosynthetic process
- response to nutrient
- fatty acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- mitochondrial matrix
- cytoplasm
- mitochondrion
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- malonyl-CoA decarboxylase activity