S100b Gene Summary [Rat]
Enables RAGE receptor binding activity; identical protein binding activity; and metal ion binding activity. Involved in several processes, including long-term synaptic potentiation; positive regulation of myelination; and response to anesthetic. Located in extracellular space. Used to study demyelinating disease. Biomarker of several diseases, including bipolar disorder; borna disease; brain edema; cerebrovascular disease (multiple); and depressive disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease; aspergillosis; and schizophrenia. Orthologous to human S100B (S100 calcium binding protein B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | S100b |
| Official Name | S100 calcium binding protein B [Source:RGD Symbol;Acc:3615] |
| Ensembl ID | ENSRNOG00000001295 |
| Bio databases IDs | |
| Aliases | S100 calcium binding protein B |
| Synonyms | AI850290, Bpb, NEF, PS-100b, S100, S100 beta, S100 calcium binding protein B, S100P, S100 protein, beta polypeptide, neural, S100 protein, β polypeptide, neural, S100 β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat S100b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- EF-hand, calcium binding motif
- S-100/ICaBP type calcium binding domain
- zinc ion binding
- tau protein binding
- hinge domain
- calcium ion binding
- protein homodimerization
- EFh
- protein binding
- receptor binding
- identical protein binding
Pathways
Biological processes and signaling networks where the S100b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- neoplasia
- breast cancer
- cerebral ischemia
- respiratory failure
- unspecified disease
- HER2 negative hormone receptor negative breast cancer
- delirium
- aortic valve calcification
- high-fat diet-induced obesity
role in cell
- expression in
- proliferation
- cellular infiltration by
- cell death
- activation in
- cell viability
- survival
- apoptosis
- formation
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- ruffle
- cilia
- Extracellular Space
- perinuclear region
- intracellular membranes
- filamentous network
- Nucleus
- Plasma Membrane
- basal bodies
- cytoplasmic aggregates
- cytosol
- membrane ruffles
- nucleoplasm
- spindle pole
- membrane processes
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat S100b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- regulation of neuronal synaptic plasticity
- axonogenesis
- positive regulation of cell proliferation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of neuron differentiation
- cell adhesion
- memory
- learning or memory
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- ruffle
- cytosol
- neuronal cell body
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- protein homodimerization activity
- protein binding
- calcium ion binding
- tau protein binding
- calcium-dependent protein binding
- S100 protein binding
- RAGE receptor binding