S100a1 Gene Summary [Rat]
Enables calcium ion binding activity; calcium-dependent protein binding activity; and identical protein binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of voltage-gated calcium channel activity. Located in M band and Z disc. Orthologous to human S100A1 (S100 calcium binding protein A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | S100a1 |
| Official Name | S100 calcium binding protein A1 [Source:RGD Symbol;Acc:3614] |
| Ensembl ID | ENSRNOG00000012410 |
| Bio databases IDs | |
| Aliases | S100 calcium binding protein A1 |
| Synonyms | S100, S100A, S100-alpha, S100 calcium binding protein A1, S100-α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat S100a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- EF-hand, calcium binding motif
- ATPase binding
- S-100/ICaBP type calcium binding domain
- EF-hand domain pair
- EF hand
- calcium ion binding
- protein homodimerization
- EFh
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rotator cuff injury
- schizophrenia
- androgenic alopecia
- Hashimoto thyroiditis
- endometriosis
- Graves disease
- pulmonary hypertension
- productive infection by HIV-1
role in cell
- apoptosis
- growth
- quantity
- motility
- shortening
- contractility
- regulation
- colony formation
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- Plasma Membrane
- sarcoplasmic reticulum
- Golgi Apparatus
- Mitochondria
- sarcomere
- cytosol
- nucleoplasm
- perinuclear space
- neuromuscular junctions
- nerve ending
- I band
- sarcoplasmic reticulum vesicle
- Z line
- actin stress fibers
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat S100a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of nitric-oxide synthase activity
- regulation of heart contraction
- intracellular signal transduction
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- sarcoplasmic reticulum
- mitochondrion
- cytosol
- macromolecular complex
- Golgi apparatus
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- calcium ion binding
- calcium-dependent protein binding
- S100 protein binding
- ATPase binding