Chac2 Gene Summary [Rat]
The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the glutathione depletion enhances apoptosis. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | Chac2 |
| Official Name | ChaC cation transport regulator 2 [Source:RGD Symbol;Acc:1309120] |
| Ensembl ID | ENSRNOG00000001531 |
| Bio databases IDs | |
| Aliases | ChaC cation transport regulator 2 |
| Synonyms | ChaC, cation transport regulator 2, ChaC glutathione specific gamma-glutamylcyclotransferase 2, ChaC glutathione specific γ-glutamylcyclotransferase 2, GCG1, RGD1309120 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chac2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amidine lyase
- GGCT_like
- gamma-glutamylcyclotransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chac2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutathione biosynthetic process
- glutathione catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- gamma-glutamylcyclotransferase activity