CHAC2 Gene Summary [Human]
The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the glutathione depletion enhances apoptosis. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | CHAC2 |
| Official Name | ChaC glutathione specific gamma-glutamylcyclotransferase 2 [Source:HGNC Symbol;Acc:HGNC:32363] |
| Ensembl ID | ENSG00000143942 |
| Bio databases IDs | |
| Aliases | ChaC glutathione specific gamma-glutamylcyclotransferase 2, gamma-GCT acting on glutathione homolog 2 |
| Synonyms | ChaC, cation transport regulator 2, ChaC glutathione specific gamma-glutamylcyclotransferase 2, ChaC glutathione specific γ-glutamylcyclotransferase 2, GCG1, RGD1309120 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHAC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amidine lyase
- GGCT_like
- gamma-glutamylcyclotransferase
- enzyme
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHAC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutathione biosynthetic process
- glutathione catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- gamma-glutamylcyclotransferase activity