Pdgfra Gene Summary [Rat]
Enables phosphatidylinositol 3-kinase binding activity and platelet-derived growth factor alpha-receptor activity. Involved in several processes, including lung growth; positive regulation of branching involved in lung morphogenesis; and positive regulation of peptidyl-tyrosine phosphorylation. Located in several cellular components, including axon; nucleus; and plasma membrane. Used to study middle cerebral artery infarction. Biomarker of chronic ulcer of skin; hypertension; oligohydramnios; pulmonary fibrosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hypereosinophilic syndrome; and pancreatic cancer. Orthologous to human PDGFRA (platelet derived growth factor receptor alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdgfra |
| Official Name | platelet derived growth factor receptor alpha [Source:RGD Symbol;Acc:3284] |
| Ensembl ID | ENSRNOG00000002244 |
| Bio databases IDs | |
| Aliases | platelet derived growth factor receptor alpha |
| Synonyms | APDGFR, CD140A, LOC102554024, PDGFACE, Pdgfar, PDGFR-2, PDGFR alpha, Pdgf receptor-α, PDGFR α, PDGF α R, Pdgf α Receptor, platelet derived growth factor receptor alpha, platelet derived growth factor receptor, alpha polypeptide, platelet derived growth factor receptor α, platelet derived growth factor receptor, α polypeptide, α-pdgfr |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdgfra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase
- platelet-derived growth factor receptor alpha
- protein-tyrosine kinase
- Protein kinase domain
- activation loop
- phospholipase activator
- cytoplasmic domain
- Immunoglobulin like
- intracellular domain
- immunoglobulin-like protein domain
- vascular endothelial growth factor receptor
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- growth factor binding
- transmembrane receptor
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- platelet-derived growth factor receptor binding
- Immunoglobulin I-set domain
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- phosphoinositide 3-kinase binding
- binding protein
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- transmembrane domain
- tyrosine kinase domain
- protein homodimerization
Pathways
Biological processes and signaling networks where the Pdgfra gene in rat plays a role, providing insight into its function and relevance in health or disease.
- CREB Signaling in Neurons
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- Human Embryonic Stem Cell Pluripotency
- IL-15 Production
- Iron homeostasis signaling pathway
- NF-κB Signaling
- PAK Signaling
- PDGF Signaling
- PPAR Signaling
- PTEN Signaling
- Sperm Motility
- Sphingosine-1-phosphate Signaling
- STAT3 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic neuropathy
- precursor B-cell acute lymphoblastic leukemia
- COVID-19
- bleeding
- vascular disease
- metastasis
- neoplasia
- epithelial cancer
- cancer
- edema
role in cell
- expression in
- growth
- apoptosis
- activation in
- proliferation
- phosphorylation in
- migration
- cell viability
- quantity
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- cilia
- cell surface
- membrane surface
- cellular membrane
- Nucleus
- Golgi Apparatus
- cytosol
- endoplasmic reticulum membrane
- plasma membrane extracellular face
- nucleoplasm
- nuclear bodies
- axon initial segments
- cellular protrusions
- microvilli
- perikaryon
- axons
- dendrites
- plasma
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdgfra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retina vasculature development in camera-type eye
- peptidyl-tyrosine phosphorylation
- multicellular organismal development
- positive regulation of cell proliferation
- palate development
- signal transduction involved in regulation of gene expression
- protein autophosphorylation
- embryonic digestive tract morphogenesis
- odontogenesis of dentin-containing tooth
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
- hemopoietic progenitor cell differentiation
- face morphogenesis
- cell chemotaxis
- positive regulation of calcium-mediated signaling
- white fat cell differentiation
- cellular response to amino acid stimulus
- regulation of mesenchymal stem cell differentiation
- wound healing
- in utero embryonic development
- positive regulation of fibroblast proliferation
- cardiac myofibril assembly
- positive regulation of kinase activity
- platelet aggregation
- adrenal gland development
- lung development
- estrogen metabolic process
- platelet-derived growth factor receptor-alpha signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- platelet-derived growth factor receptor signaling pathway
- embryonic cranial skeleton morphogenesis
- embryonic skeletal system morphogenesis
- luteinization
- cell activation
- regulation of actin cytoskeleton organization
- male genitalia development
- metanephric glomerular capillary formation
- positive regulation of ERK1 and ERK2 cascade
- extracellular matrix organization
- negative regulation of platelet activation
- cellular response to reactive oxygen species
- Leydig cell differentiation
- positive regulation of chemotaxis
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- Golgi apparatus
- receptor complex
- plasma membrane
- nucleoplasm
- endoplasmic reticulum membrane
- nucleus
- cytoplasm
- microvillus
- membrane
- cilium
- cell junction
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- platelet-derived growth factor alpha-receptor activity
- protein homodimerization activity
- protein binding
- platelet-derived growth factor receptor binding
- transmembrane receptor protein tyrosine kinase activity
- vascular endothelial growth factor-activated receptor activity
- protein kinase activity
- vascular endothelial growth factor binding
- platelet-derived growth factor binding