Ece2 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide hormone processing. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in plasma membrane. Orthologous to human EEF1AKMT4-ECE2 (EEF1AKMT4-ECE2 readthrough) and ECE2 (endothelin converting enzyme 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ece2 |
| Official Name | endothelin-converting enzyme 2 [Source:RGD Symbol;Acc:1303039] |
| Ensembl ID | ENSRNOG00000001715 |
| Bio databases IDs | |
| Aliases | endothelin-converting enzyme 2 |
| Synonyms | 1810009K13RIK, EEF1AKMT4, endothelin-converting enzyme 2, MGC2408 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ece2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- metallopeptidase
- peptidase
- protein binding
- peptidase GluZincin family
- Peptidase family M13
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Ece2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cytoplasmic vesicle membrane
- Cytoplasm
- cellular membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ece2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- cell-cell signaling
- protein processing
- peptide hormone processing
- methylation
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- transport vesicle membrane
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- methyltransferase activity
- metalloendopeptidase activity