Comt Gene Summary [Rat]
Enables catechol O-methyltransferase activity. Involved in several processes, including learning or memory; positive regulation of homocysteine metabolic process; and response to olanzapine. Located in several cellular components, including cell body; dendritic spine; and postsynaptic membrane. Is active in glutamatergic synapse and postsynapse. Used to study Parkinsonism and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of skin and connective tissue (multiple); cognitive disorder (multiple); drug dependence (multiple); reproductive organ cancer (multiple); and withdrawal disorder (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Comt |
| Official Name | catechol-O-methyltransferase [Source:RGD Symbol;Acc:2379] |
| Ensembl ID | ENSRNOG00000001889 |
| Bio databases IDs | |
| Aliases | catechol-O-methyltransferase |
| Synonyms | Catechol-o-methyltransferase, Comt1, D16Wsu103e, D330014B15RIK, HEL-S-98n |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Comt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyltransferase
- O-methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- catechol O-methyltransferase
Pathways
Biological processes and signaling networks where the Comt gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic Parkinson disease
- breast cancer
- hypertension
- Parkinson disease
- systolic hypertension
- schizophrenia
- addiction
- Parkinson disease with end-of-dose motor fluctuations
- motor fluctuations
- non-insulin-dependent diabetes mellitus
role in cell
- number
- quantity
- proliferation
- cell death
- response
- response by
- metabolism in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- intracellular membrane-bounded organelle
- Extracellular Space
- postsynaptic region
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- Endoplasmic Reticulum
- cytosol
- postsynaptic membrane
- dendritic spines
- glial cell projections
- membrane rafts
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Comt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- response to cytokine stimulus
- multicellular organism growth
- norepinephrine metabolic process
- dopamine metabolic process
- exploration behavior
- dopamine secretion
- habituation
- response to wounding
- visual learning
- response to xenobiotic stimulus
- artery development
- response to toxin
- renin secretion into blood stream
- memory
- cerebellar cortex morphogenesis
- norepinephrine secretion
- response to oxidative stress
- synaptic transmission, dopaminergic
- response to hypoxia
- startle response
- renal filtration
- cellular response to cocaine
- renal sodium excretion
- cellular response to phosphate starvation
- developmental process
- prostaglandin metabolic process
- dopamine catabolic process
- catecholamine catabolic process
- behavioral fear response
- response to corticosterone stimulus
- glycogen metabolic process
- glomerulus development
- response to amphetamine
- renal albumin absorption
- gene expression
- cholesterol efflux
- mastication
- detection of temperature stimulus involved in sensory perception of pain
- methylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- cytosol
- synapse
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- catechol O-methyltransferase activity
- O-methyltransferase activity
- protein binding
- methyltransferase activity