Angpt2 Gene Summary [Rat]
Predicted to enable receptor ligand activity and receptor tyrosine kinase binding activity. Involved in several processes, including blood vessel development; maternal process involved in female pregnancy; and positive regulation of angiogenesis. Located in cell projection and extracellular space. Used to study several diseases, including ischemia (multiple); membranoproliferative glomerulonephritis; portal hypertension; retinal disease (multiple); and uremia. Biomarker of several diseases, including Caroli disease; artery disease (multiple); gastric ulcer; glomerulonephritis (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human ANGPT2 (angiopoietin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Angpt2 |
| Official Name | angiopoietin 2 [Source:RGD Symbol;Acc:621861] |
| Ensembl ID | ENSRNOG00000016696 |
| Bio databases IDs | |
| Aliases | angiopoietin 2 |
| Synonyms | AGPT2, ANG2, ANG II, angiopoietin 2, Angiotensin 2, Angiotensin II, Angp2, Angrp, LMPHM10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Angpt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor tyrosine kinase binding
- receptor antagonist activity
- fibrinogen-like domain
- coiled-coil domain
- receptor agonist activity
- protein binding
- receptor binding
- vascular endothelial growth factor receptor binding
- FReD
- growth factor
Pathways
Biological processes and signaling networks where the Angpt2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- hypertension
- neoplasia
- metastasis
- glioblastoma
- cardiomyopathy
- abscess
- exudative age-related macular degeneration
- organismal death
- diabetic macular edema
role in cell
- dephosphorylation in
- expression in
- proliferation
- accumulation in
- activation
- differentiation
- phosphorylation in
- binding
- quantity
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Plasma Membrane
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Angpt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- negative regulation of angiogenesis
- negative regulation of blood vessel endothelial cell migration
- maternal process involved in female pregnancy
- negative regulation of positive chemotaxis
- signal transduction
- response to organic cyclic compound
- positive regulation of angiogenesis
- response to mechanical stimulus
- response to glucose stimulus
- response to hypoxia
- negative regulation of cell-substrate adhesion
- angiogenesis
- Tie receptor signaling pathway
- cellular response to growth factor stimulus
- glomerulus vasculature development
- gene expression
- organ regeneration
- response to activity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- cell projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- receptor binding
- receptor tyrosine kinase binding