Hsd17b11 Gene Summary [Rat]
Predicted to enable estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Predicted to be involved in androgen catabolic process. Predicted to be located in cytoplasm. Predicted to be active in lipid droplet. Orthologous to human HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hsd17b11 |
| Official Name | hydroxysteroid (17-beta) dehydrogenase 11 [Source:RGD Symbol;Acc:1303235] |
| Ensembl ID | ENSRNOG00000002210 |
| Bio databases IDs | |
| Aliases | hydroxysteroid (17-beta) dehydrogenase 11 |
| Synonyms | 17-BETA-HSD11, 17-BETA-HSDXI, 17-beta-hydroxysteroid dehydrogenase 11, 17BHSD11, 17-β-HSD11, 17-β-HSDXI, 17-β-hydroxysteroid dehydrogenase 11, DHRS8, hydroxysteroid (17-beta) dehydrogenase 11, hydroxysteroid 17-beta dehydrogenase 11, hydroxysteroid (17-β) dehydrogenase 11, hydroxysteroid 17-β dehydrogenase 11, LOC51170, PAN1B, RETSDR2, SDR16C2, SDR2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hsd17b11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- estradiol 17beta-dehydrogenase
- SDR family mycofactocin-dependent oxidoreductase
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
- steroid dehydrogenase
Pathways
Biological processes and signaling networks where the Hsd17b11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- major depression
- colon cancer
- nonalcoholic steatohepatitis
- peripheral arterial disease
- early onset hypertension
regulates
- lipid
- superoxide
- PNPLA2
- androgen
- estrogen
- triacylglycerol
role in cell
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- cell cortex
- lipid droplets
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hsd17b11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- estrogen biosynthetic process
- androgen catabolic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- cytoplasm
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- estradiol 17-beta-dehydrogenase activity
- steroid dehydrogenase activity
- protein binding
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor