Cybc1 Gene Summary [Rat]

Predicted to be involved in innate immune response and respiratory burst after phagocytosis. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in autosomal recessive chronic granulomatous disease 5. Orthologous to human CYBC1 (cytochrome b-245 chaperone 1). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Cybc1
Official Name
cytochrome b-245 chaperone 1 [Source:RGD Symbol;Acc:1562022]
Ensembl ID
ENSRNOG00000036666
Bio databases IDs NCBI: 619574 Ensembl: ENSRNOG00000036666
Aliases cytochrome b-245 chaperone 1
Synonyms C17orf62, CGD5, cytochrome b-245 chaperone 1, Eros
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cybc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Cytochrome b-245 chaperone 1 / Eros
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • follicular B-cell lymphoma
  • follicular non-Hodgkin disease
  • autosomal recessive chronic granulomatous disease type 5
regulated by
  • tetradecanoylphorbol acetate
regulates
role in cell
  • production in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Endoplasmic Reticulum

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Cybc1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • respiratory burst after phagocytosis
  • innate immune response

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • endoplasmic reticulum

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

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