Gabra2 Gene Summary [Rat]
Predicted to enable GABA-gated chloride ion channel activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and inhibitory synapse assembly. Located in dendrite membrane. Is active in GABA-ergic synapse; postsynaptic specialization membrane; and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; autistic disorder; and developmental and epileptic encephalopathy 78. Orthologous to human GABRA2 (gamma-aminobutyric acid type A receptor subunit alpha2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabra2 |
| Official Name | gamma-aminobutyric acid type A receptor alpha2 subunit [Source:RGD Symbol;Acc:61856] |
| Ensembl ID | ENSRNOG00000002349 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid type A receptor alpha2 subunit |
| Synonyms | C630048P16Rik, DEE78, EIEE78, Gaba A receptor alpha-2, GABA A receptor subunit alpha 2, GABA A receptor subunit α 2, Gaba A receptor α-2, gamma-aminobutyric acid type A receptor subunit alpha 2, α 2 gaba receptor, γ-aminobutyric acid type A receptor subunit alpha2, γ-aminobutyric acid type A receptor subunit α 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gabra2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- intracellular loop
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- intracellular M3-M4 domain
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- benzodiazepine receptor
- ion channel
- anion channel
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- chloride channel
- ligand-gated ion channel
- intracellular domain
- loop domain
Pathways
Biological processes and signaling networks where the Gabra2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- hypertension
- hypercholesterolemia
- nonalcoholic fatty liver disease
- HIV infection
- cancer
- dental caries
- diabetes mellitus
- pain
- dementia
role in cell
- proliferation
- expression in
- activation in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- synaptic vesicle membrane
- Cytoplasm
- postsynaptic region
- membrane surface
- cellular membrane
- presynaptic membrane
- synaptic membrane
- synaptosomes
- synapse
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gabra2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- synaptic transmission, GABAergic
- gamma-aminobutyric acid signaling pathway
Cellular Component
Where in the cell the gene product is active
- inhibitory synapse
- chloride channel complex
- dendrite membrane
- synaptic vesicle membrane
- synapse
- neuronal cell body
- neuron projection
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GABA-A receptor activity
- chloride channel activity
- benzodiazepine receptor activity
- GABA-gated chloride ion channel activity