Arhgef9 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in receptor clustering. Located in cell cortex. Is active in GABA-ergic synapse; glycinergic synapse; and postsynaptic specialization. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 8. Orthologous to human ARHGEF9 (Cdc42 guanine nucleotide exchange factor 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Arhgef9 |
| Official Name | Cdc42 guanine nucleotide exchange factor 9 [Source:RGD Symbol;Acc:620719] |
| Ensembl ID | ENSRNOG00000007733 |
| Bio databases IDs | |
| Aliases | Cdc42 guanine nucleotide exchange factor 9 |
| Synonyms | 9630036L12Rik, Cb, CDC42 guanine nucleotide exchange factor 9, COLLYBISTIN, DEE8, EIEE8, HPEM-2, LOC100912165, PEM-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgef9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Arhgef9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperekplexia and epilepsy
- hereditary disorder
- COVID-19
- alopecia
- developmental disorder
- X-linked complex neurodevelopmental disorder
- global developmental delay
role in cell
- formation
- binding in
- cell rounding
- loss in
- long-term potentiation
- plasticity
- abnormal morphology
- excitatory postsynaptic potential
- long term synaptic depression
- clustering in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- organelle
- cell cortex
- cytosol
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgef9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity