Ivns1abp Gene Summary [Rat]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to virus. Predicted to act upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Predicted to be located in cytosol and nucleus. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 70. Orthologous to human IVNS1ABP (influenza virus NS1A binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ivns1abp |
| Official Name | influenza virus NS1A binding protein [Source:RGD Symbol;Acc:1306290] |
| Ensembl ID | ENSRNOG00000002618 |
| Bio databases IDs | |
| Aliases | influenza virus NS1A binding protein |
| Synonyms | 1190004M08Rik, 1700126I16Rik, ARA3, FLARA3, HSPC068, IMD70, influenza virus NS1A binding protein, KLHL39, LOC102724641, mKIAA0850, ND1, Nd1-L, Nd1-S, NS-1, NS1-BP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ivns1abp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
- intervening region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- ascites
- Huntington disease
- lung metastasis
- lung cancer
- metastasis
- thoracic cancer
- advanced cancer
- lymphomagenesis
- hematologic cancer
role in cell
- expression in
- apoptosis
- cell death
- growth
- migration
- binding in
- BI-2536 sensitivity
- invasion by
- nucleocytoplasmic shuttling in
- cytokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- spliceosomes
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ivns1abp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- transcription from RNA polymerase III promoter
- intrinsic apoptotic signaling pathway
- negative regulation of protein ubiquitination
- response to virus
- negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- cytoskeleton
- cytosol
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding