Nck1 Gene Summary [Rat]
Predicted to enable several functions, including eukaryotic initiation factor eIF2 binding activity; molecular condensate scaffold activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antiviral innate immune response; regulation of gene expression; and regulation of signal transduction. Predicted to act upstream of or within several processes, including actin filament organization; plasma membrane bounded cell projection assembly; and positive regulation of cellular component organization. Predicted to be located in several cellular components, including cell-cell junction; endoplasmic reticulum; and ribosome. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in cytoplasm. Orthologous to human NCK1 (NCK adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nck1 |
| Official Name | NCK adaptor protein 1 [Source:RGD Symbol;Acc:1310688] |
| Ensembl ID | ENSRNOG00000014917 |
| Bio databases IDs | |
| Aliases | NCK adaptor protein 1 |
| Synonyms | 6330586M15Rik, D230010O13RIK, NCK, NCK adaptor protein 1, NCKalpha, Nck α, non-catalytic region of tyrosine kinase adaptor protein 1, p47Nck |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nck1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- SH3 domain
- receptor tyrosine kinase binding
- protein kinase inhibitor activity
- protein binding activity, bridging
- Src homology 2 (SH2) domain
- protein domain specific binding
- ephrin receptor binding
- protein binding
- receptor binding
- Src-homology 2 binding domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Nck1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Angiopoietin Signaling
- Axonal Guidance Signaling
- Ephrin A Signaling
- Ephrin Receptor Signaling
- ErbB Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- G Protein Signaling Mediated by Tubby
- GDNF Family Ligand-Receptor Interactions
- Insulin Receptor Signaling
- Integrin Signaling
- Natural Killer Cell Signaling
- Netrin Signaling
- PAK Signaling
- Paxillin Signaling
- T Cell Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- chronic lymphocytic leukemia
- osteoarthritis
- idiopathic habitual abortion
- myocardial infarction
- osteopenia
- neuroticism
role in cell
- expression in
- cell death
- binding
- survival
- quantity
- activation in
- apoptosis
- phosphorylation in
- proliferation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosomal fraction
- lysosome fractions
- detergent-insoluble fractions
- membrane fraction
- invadopodia
- cellular membrane
- focal adhesions
- ribosome
- Plasma Membrane
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- ER-to-Golgi intermediate compartment
- cytosol
- vesicle membrane
- Z line
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
- filopodia
- perikaryon
- axons
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nck1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal complex assembly
- T cell activation
- actin filament organization
- positive regulation of T cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- substrate-dependent cell migration, cell extension
- negative regulation of insulin receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- ephrin receptor signaling pathway
- positive regulation of actin filament polymerization
- negative regulation of peptidyl-serine phosphorylation
- lamellipodium assembly
- positive regulation of neuron projection development
- regulation of cell migration
- cell migration
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- nucleus
- protein phosphatase type 1 complex
- cell-cell junction
- cytoplasm
- vesicle membrane
- cytosol
- endoplasmic reticulum
- ribosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- cytoskeletal adaptor activity
- signaling adaptor activity
- ephrin receptor binding
- receptor binding
- protein kinase inhibitor activity
- protein binding
- eukaryotic initiation factor eIF2 binding
- cadherin binding
- receptor tyrosine kinase binding
- protein binding, bridging
- receptor signaling complex scaffold activity