Emp2 Gene Summary [Rat]
Predicted to enable integrin binding activity and kinase binding activity. Predicted to be involved in several processes, including bleb assembly; early endosome to late endosome transport; and embryonic process involved in female pregnancy. Predicted to act upstream of or within positive regulation of cell-matrix adhesion. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in nephrotic syndrome type 10. Orthologous to human EMP2 (epithelial membrane protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Emp2 |
| Official Name | epithelial membrane protein 2 [Source:RGD Symbol;Acc:1359629] |
| Ensembl ID | ENSRNOG00000002664 |
| Bio databases IDs | |
| Aliases | epithelial membrane protein 2 |
| Synonyms | epithelial membrane protein 2, IMGAE 4717000, XMP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Emp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- protein kinase binding
- integrin binding
- PMP-22/EMP/MP20/Claudin family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck neoplasia
- cancer
- epithelial cancer
- eating disorder
- nephrotic syndrome type 10
- nasopharyngeal cancer
- epithelial neoplasia
- pharyngeal cancer
- pharyngeal neoplasia
- head and neck cancer
role in cell
- adhesion
- proliferation
- tumorigenicity
- apoptosis
- cell death
- migration by
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- apical compartment
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- apical membrane
- cytoplasmic vesicles
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Emp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- regulation of kinase activity
- protein localization at cell surface
- regulation of glomerular filtration
- positive regulation of cell proliferation
- regulation of angiogenesis
- actin filament organization
- cell adhesion
- positive regulation of angiogenesis
- natural killer cell proliferation
- membrane raft assembly
- apoptotic process
- activation of protein kinase activity
- positive regulation of integrin-mediated signaling pathway
- cell migration
- cell-matrix adhesion
- regulation of endothelial cell migration
- caveola assembly
- bleb assembly
- embryonic process involved in female pregnancy
- blood vessel endothelial cell migration
- embryo implantation
- regulation of cell-matrix adhesion
- heart formation
- positive regulation of cell-matrix adhesion
- actin-mediated cell contraction
- early endosome to late endosome transport
- T cell mediated cytotoxicity
- regulation of vasculogenesis
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
- plasma membrane
- cell surface
- nucleus
- caveola
- perinuclear region of cytoplasm
- apical part of cell
- cytoplasm
- membrane
- membrane raft
- cytoplasmic vesicle
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- integrin binding
- kinase binding