Itga5 Gene Summary [Rat]
Enables epidermal growth factor receptor binding activity and integrin binding activity. Involved in several processes, including female pregnancy; integrin-mediated signaling pathway; and positive regulation of cell-substrate adhesion. Part of integrin complex. Is active in glutamatergic synapse and postsynaptic membrane. Orthologous to human ITGA5 (integrin subunit alpha 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itga5 |
| Official Name | integrin subunit alpha 5 [Source:RGD Symbol;Acc:2925] |
| Ensembl ID | ENSRNOG00000057451 |
| Bio databases IDs | |
| Aliases | integrin subunit alpha 5 |
| Synonyms | CD49e, FNRA, integrin alpha 5 (fibronectin receptor alpha), integrin subunit alpha 5, integrin subunit α 5, Integrin α 5, integrin α 5 (fibronectin receptor α), ITA5, Itga5 retired, ITGalpha5, ITGα5, VLA-5, VLA5A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itga5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- cell adhesion molecule binding
- epidermal growth factor receptor binding
- platelet-derived growth factor receptor binding
- calcium ion binding
- protein binding
- vascular endothelial growth factor receptor binding
- FG-GAP-like repeat
- GFFKR motif
- Integrin alpha (beta-propellor repeats)
- Integrin alpha
- cytoplasmic domain
- integrin binding
- transmembrane domain
- intracellular domain
- cytosolic tail domain
- FG-GAP repeat
- PDZ binding motif
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Itga5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Agranulocyte Adhesion and Diapedesis
- Caveolar-mediated Endocytosis Signaling
- Clathrin-mediated Endocytosis Signaling
- Ephrin Receptor Signaling
- ERK/MAPK Signaling
- HGF Signaling
- Macropinocytosis Signaling
- Molecular Mechanisms of Cancer
- PAK Signaling
- Paxillin Signaling
- PTEN Signaling
- Rac Signaling
- Reelin Signaling in Neurons
- Regulation of Actin-based Motility by Rho
- Regulation of Cellular Mechanics by Calpain Protease
- Regulation of eIF4 and p70S6K Signaling
- RhoGDI Signaling
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Sertoli Cell-Sertoli Cell Junction Signaling
- TR/RXR Activation
- TREM1 Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pulmonary fibrosis
- liver cancer
- epithelial cancer
- organismal death
- gastric cancer
- growth failure
- pancreatic cancer
- survival
- endometriosis
role in cell
- cell death
- expression in
- accumulation
- apoptosis
- proliferation
- activation in
- cell viability
- migration
- signaling in
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- ruffle
- extracellular vesicles
- Cytoplasm
- cell-matrix contacts
- cell surface
- cell borders
- Extracellular Space
- intracellular space
- membrane surface
- cellular membrane
- focal complexes
- focal adhesions
- endosomes
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- granules
- membrane ruffles
- plasma membrane extracellular face
- postsynaptic membrane
- perinucleolar compartments
- synapse
- recycling endosomes
- early endosomes
- cytoplasmic vesicles
- multivesicular bodies
- filopodia
- cell membrane leading edge
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itga5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- cell-matrix adhesion
- cell-substrate junction assembly
- heterophilic cell-cell adhesion
- female pregnancy
- cell adhesion
- memory
- leukocyte cell-cell adhesion
- cell adhesion mediated by integrin
- integrin-mediated signaling pathway
- CD40 signaling pathway
- negative regulation of anoikis
- angiogenesis
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- endodermal cell differentiation
- cell-cell adhesion mediated by integrin
- positive regulation of cell-substrate adhesion
- heterotypic cell-cell adhesion
- cell-substrate adhesion
- wound healing, spreading of epidermal cells
- positive regulation of peptidyl-tyrosine phosphorylation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- endoplasmic reticulum
- Golgi apparatus
- integrin complex
- plasma membrane
- cell surface
- alphav-beta3 integrin-vitronectin complex
- cell-cell junction
- focal adhesion
- postsynaptic membrane
- ruffle
- cytoplasmic vesicle
- ruffle membrane
- alpha5-beta1 integrin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- platelet-derived growth factor receptor binding
- vascular endothelial growth factor receptor 2 binding
- calcium ion binding
- epidermal growth factor receptor binding
- integrin binding
- viral receptor activity