Adam11 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in behavioral response to chemical pain; establishment of protein localization; and proteolysis. Predicted to be located in membrane. Orthologous to human ADAM11 (ADAM metallopeptidase domain 11). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adam11 |
| Official Name | ADAM metallopeptidase domain 11 [Source:RGD Symbol;Acc:1307515] |
| Ensembl ID | ENSRNOG00000002753 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase domain 11 |
| Synonyms | ADAM metallopeptidase domain 11, a disintegrin and metallopeptidase domain 11, AW060611, MDC |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adam11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reprolysin family propeptide
- metallopeptidase
- ZnMc
- ADAM cysteine-rich
- Metallo-peptidase family M12B Reprolysin-like
- peptidase
- integrin binding
- Disintegrin
- Reprolysin (M12B) family zinc metalloprotease
- protein binding
Pathways
Biological processes and signaling networks where the Adam11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adam11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of protein localization
- integrin-mediated signaling pathway
- behavioral response to acetic acid induced pain
- proteolysis
- multicellular organismal response to stress
- behavioral response to formalin induced pain
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- perikaryon
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- integrin binding
- metalloendopeptidase activity
- metallopeptidase activity